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The Joker, a well-known antagonist in the Batman film series, does not possess any superpowers. He is born with an extraordinary intelligence and unpredictable nature.
Black Mask is a supervillain seen in Batman films. Regarded as a brutal and ruthless crime lord, he is seen wearing masks and derives sadistic pleasure from the act of torture.
One of the most popular antagonists is Lex Luthor, who is best known as the archenemy of Superman. Despite lacking superpowers, Luthor is a cunning and merciless scientist.
In contrast to many villains, Helmut Zemo, who appears in Captain America: Civil War, is a skilled fighter without any superpowers.
Johann Schmidt - aka Red Skull - one of Captain America's biggest foes and one of Earth's most dangerous threats, also did not have any superpowers.
Harvey Dent, a.k.a. Two-Face, is an antagonist in the Batman films. Despite lacking superpowers, he is well-known for having two personalities.
He is not just a brilliant psychologist and scientist, but also a villain in the Batman series. He is known for being one of Batman's earliest and most intelligent foes.
Justin Hammer is depicted as a villainous entrepreneur, and a frequent adversary of the superhero Iron Man. He too did have any superpowers.